UK, Europe and the
Rest of the World
Telephone: +44 1638 782610
Fax: +44 1638 782611
Email:orders@moleculardimensions.com
USA, Canada, and Mexico
Telephone: +1 877 479 4339
Fax: +1 407 886 4444
Email:usorders@moleculardimensions.com
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CrystalHarp™ - Maximum sampling, minimum handling!
Wouldn't it be nice to be able to screen for crystal growth, optimize, cryo-protect and diffract in an easy-to-use format without ever handling the crystal itself?
Whilst the traditional sparse matrix approach works well, it only samples a single end-point in protein phase space; capillary based counter diffusion screening allows the establishment of a fine gradient of protein/precipitant concentration, increasing the chance of getting that elusive diffraction quality crystal. Quartz capillaries have the added benefit of allowing in-situ X-ray diffraction without the background scatter from plastic plates.
CrystalHarp is a new SBS format plate with quartz capillaries, allowing crystal growth and optimization with in-situ X-ray diffraction in the plate, or the individual capillaries can be mounted in standard CryoCaps. In other words, from screening to data collection with minimum handling.
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Features of CrystalHarp
- 48 quartz capillaries per plate allowing use of the successful interface diffusion method.
- Proven experiment length (30mm) samples large amounts of crystallization phase space.
- In-situ X-ray diffraction – shoot through the plate or mount individual capillaries in standard CryoCaps (no special equipment needed). No scale-up needed.
- Unique capillary material allows RT data collection or cryo-cooled in a liquid nitrogen stream (with or without the use of cryo protectants).
- SBS format suitable for high-throughput imaging.
- Simple set-up and analysis, seal with tape or oil.
- Gentle introduction of cryo-protectants or derivatives for phasing studies.
- Compatible with all storage and imaging systems – no additional holders needed
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