Structure Screen 1 + 2 HT-96 MD1-30

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Structure Screen 1 + 2 is formulated for the crystallization of

  • Proteins
  • Peptides
  • Nucleic acids
  • Water soluble small molecules.
This classic standard sparse matrix screen lets you:
  • Determine initial crystallization condition.
  • Establish the solubility of a macromolecule in a varying range of pH and precipitants.
  • Enables screening of greater crystallization space due to the enhanced buffer selection.

Originally published in 1991 by Jancarik & Kim from conditions found to be successful in the crystallization of biological macromolecules.
A comparison of three commercial sparse matrix screens, (Wooh et al, 2003) reported dramatically different results when comparing Crystal Screens and Structure Screens. In 38 cases the Structure Screens were more successful in producing crystals than the Crystal Screens while the opposite was the case in 26 formulations. The formulations are not identical as in several buffers Molecular Dimensions uses glacial acetic acid to adjust the pH rather than HCl. This formulation was chosen from current practice developed from experience at major UK research institutions.

References:

Jancarik, J & Kim, S.H.J. (1991), J.Appl.Cryst. 24, 409-411
Wooh et al, (2003), Acta Cryst , D59, 769 - 772.

Read about the Classical crystal growth screening approach to protein crystallography.

Learn about Modern crystal growth screening.

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