Naomi's Nucleant MD2-07

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Naomi’s Nucleant has facilitated the crystallization of 14 proteins, the highest number reported for any single nucleant. Many of these proteins have proven difficult to crystallize and some of these, including membrane proteins, have only been crystallized in the presence of Naomi’s Nucleant.

Naomi’s Nucleants are made from bio-glass material (CaO-P2O5-SiO2) and has a highly porous surface with cavities of similar sizes to proteins (see image right).


Examples of proteins crystallized in the presence of Naomi’s nucleants are:

  1. A multi drug resistance protein (a membrane protein).
  2. Modified cyclodextrine.
  3. Oxyntomodulin.
  4. Myosin binding protein C.
  5. Lobster shell, α crustacyanin.
  6. C-phycocyanin.
  7. A-actinin - actin binding protein.


References:
Saridakis, E. and Chayen N.E., "Towards a 'universal' nucleant for protein crystallization". Trends in Biotechnology (2009), 99-106.
Eisenstein, M. " The shape of things". Nature Methods (2007) 4, 95-101.
Chayen, N.E., Saridakis, E. and Sear R. "Experiment and theory for heterogeneous nucleation of protein crystals in a porous medium". PNAS (2006), Vol 103 (3).

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