Nuclear Receptors


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Nuclear Receptors

A rational approach to screening initial crystallization conditions of nuclear receptors ligand binding domains.

The NR-LBD™ screen contains 48 conditions divided into two parts: 24 conditions using various PEGs as the precipitant and 24 conditions using various carboxylic acids as the precipitant.The extension contains a set of 48 unique reagents which not only allows the user to reproduce previously obtained results but also to crystallize new ligand binding domains.

Features of the Nuclear Receptor - Ligand Binding Domain™ screen:

  • Nuclear receptors usually crystallize in the presence of two reagent families: polyethylene glycol and carboxylic acids.
  • The pH range for crystallization is 6.0 to 9.0.
  • Includes PEGs 4000, 6000 and 8000.
  • Includes sodium formate, sodium citrate, sodium acetate carboxylic acids.
  • Ionic strength controlled with sodium chloride and ammonium acetate. pH range is between 6.5 and 8.5 using Bis-Tris (pH 6.5), PIPES (pH 7.0), sodium HEPES (pH 7.5) and Tris (pH 8.0 and 8.5).

Also effective with other soluble proteins.

*The NR-LBD screen and the NR-LBD extension screen were developed by Denis Zeyer, Sylvie Duclaud, Dino Moras and Jean-Paul Renaud at The Institute of Genetics and Molecular and Cell Biology, CNRS, UMR 7104, Illkirch, France and is manufactured under an exclusive licence from CNRS, France.

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