Additive Screens

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Additive Screens

Crystals can be further improved by adding substrate analogues, inhibitors, ligands or other additives.
Some tips for additive screening.

Additive Screening can be useful for small/poorly diffracting crystals or too much nucleation. There are a variety of approaches that can be taken:

  • Using any of our additive screens (for soluble or membrane proteins) - use your hit condition as a base.
  • Look for chemical entities in common amongst your initial hits. Re-screen with one or more of the primary screens using this entity as an additive.
  • If your protein is known to bind a ligand, re-screen with one or more of the primary screens using the ligand as an additive.
  • Perform a thermofluor experiment testing your protein against the additive screens. If you observe a significant stabilisation of your protein, re-screen with one or more of the primary screens using the stabilising condition as an additive.

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    Calixar C2B

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