The MemGold™ screens are the result of data mining of successful crystallization conditions for alpha helical prokariotic and eukariotic membrane proteins.
In 2008 Molecular Dimensions released MemGold™; a rationalized sparse matrix type membrane protein crystallization screen.
MemGold™ was based on the crystallization conditions for 121 alpha helical membrane proteins deposited in the PDB.
Features of MemGold™:
- Data mined from 300 crystallization conditions for a-helical transmembrane proteins.
- Covers conditions for approximately 130 different membrane protein structures in the PDB.
- Addresses the diversity of membrane proteins studied.
"In the Newstead group we typically use ... MemGold and MemGold2 and now include both MemTrans and MemChannel as standard to try and increase the chance of success. If a group is limited in the number of screens it can purchase then I would start with [MemGold and MemGold2] and then choose either MemTrans or MemChannel depending on the protein type of interest." Dr Joanne Parker, University of Oxford, MemGold screen family co-developer.
Developed by members of the So Iwata Lab, Imperial College, London.
This product is manufactured under an exclusive license from Imperial College of Science, Technology & Medicine, London, UK.
Simon Newstead, Sébastien Ferrandon, and So Iwata Rationalizing α-helical membrane protein crystallization Protein Sci 2008 17: 466-472.
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