MemChannel™

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MemChannel™

The first crystallization screen developed specifically for ion channel proteins:

  • MemChannel™* uniquely targets ion channel proteins.
  • Includes the most common ion channel crystallization conditions to maximize your chances of success.
  • Continually updated database3 ensures most recent hit conditions are present.
  • Hand-curated to remove false positives from unrelated structures – only ion channel crystallizations contribute to the formulation.
  • Developed by Prof. Simon Newstead and Dr Joanna Parker who developed our popular MemGold™ screens.
  • Exclusively available from Molecular Dimensions.

Since releasing the popular MemGold and MemGold II1,2 screens, Prof. Simon Newstead of Oxford University has continued to hand-curate his database3 of α-helical membrane protein structures and their crystallization conditions.

The database3 is now large enough to allow robust analysis of functional sub-groups within the dataset as a whole. This has resulted in the development of a new-generation of screens, including MemChannel, focused on particular classes of membrane protein.

Ion channels represent around 30% of all known membrane protein structures. MemChannel gives you the best chance of crystallising your channel of interest. According to Dr Joanne Parker, ion channels, which often possess large soluble domains, require higher salt concentrations and either a lower percentage of small or medium PEG or a low percentage of a large PEG. In addition, channels have a trimodel pH profile with peaks at 4.5, 6.5 and 8. MemChannel's conditions are based on these observations and covers all the most common conditions for ion channel crystallization.

"In the Newstead group we typically use ... MemGold and MemGold2 and now include both MemTrans and MemChannel as standard to try and increase the chance of success. If a group is limited in the number of screens it can purchase then I would start with [MemGold and MemGold2] and then choose either MemTrans or MemChannel depending on the protein type of interest." Dr Joanne Parker, University of Oxford, MemGold screen family co-developer.

References

  1. Newstead, S., Ferrandon, S., Iwata, S. Protein Science 17: 466-472 (2008).
  2. Parker, J. and Newstead, S. Protein Science 21: 1358-1365 (2012).
  3. Parker, J. L. and Newstead, S. Adv. Exp. Med. Biol. 922: 61-72 (2016).


*Developed by Prof. Simon Newstead and Dr Joanne Parker of Oxford University and exclusively licensed to Molecular Dimensions Ltd by Oxford University Innovation.



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