MemTrans™

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MemTrans™

A unique screen designed for transporter proteins:


  • MemTrans uniquely targets transporter proteins.
  • Includes the most common transporter protein crystallization conditions to maximize your chances of success.
  • Continually updated database1,2 ensures most recent hit conditions are present.
  • Hand-curated database3 to remove false positives from unrelated structures – only transporter protein conditions contribute to the formulation.
  • Developed by Prof. Simon Newstead and Dr Joanna Parker who developed our popular MemGold screens.
  • Exclusively available from Molecular Dimensions.

Since releasing the popular MemGold and MemGold II1,2 screens, Prof Simon Newstead of Oxford University has continued to hand-curate his database3 of α-helical membrane protein structures and their crystallization conditions.

The database is now large enough to allow robust analysis of functional sub-groups within the dataset as a whole. This has resulted in the development of a new-generation of screens, including MemTrans, focused on particular classes of membrane protein.

Approximately 30% of all known membrane protein structures are transporter proteins. Transporters, which do not generally have large soluble domains, tend to crystallize in higher percentages of small Molecular Weight PEGS, with a skewed normal distribution of pH having a maxima of 7-7.5, according to the analysis by Prof Newstead and Dr Parker. MemTrans contains conditions based on these observations, and brings together all the most common transporter protein crystallization conditions in one place. Crystallising your transporter protein has never been so easy.

"In the Newstead group we typically use ... MemGold and MemGold2 and now include both MemTrans and MemChannel as standard to try and increase the chance of success. If a group is limited in the number of screens it can purchase then I would start with [MemGold and MemGold2] and then choose either MemTrans or MemChannel depending on the protein type of interest." Dr Joanne Parker, University of Oxford, MemGold screen family co-developer.

References

  1. Newstead, S., Ferrandon, S., Iwata, S. Protein Science 17: 466-472 (2008).
  2. Parker, J. and Newstead, S. Protein Science 21: 1358-1365 (2012).
  3. Parker, J. L. and Newstead, S. Adv. Exp. Med. Biol 922: 61-72 (2016).


*Developed by Prof Simon Newstead and Dr Joanne Parker of Oxford University and exclusively licensed to Molecular Dimensions Ltd by Oxford University Innovation.



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