MemChannel and MemTrans

The first screens to target specific functional and structural subsets of membrane proteins.

FeaturesTwo new screens that uniquely target specific functional groups of membrane proteins. MemChannel targets ion channels, while MemTrans is specific for transporter proteins.

Our popular MemGold™1 and MemGold2™1,2 screens have enabled the crystallisation of many membrane protein structures. The developer of those screens, Prof Simon Newstead of Oxford University, has continued to maintain his hand-curated database3 of α-helical membrane protein structures and their crystallisation conditions.

Today, this dataset3 is large enough that it is possible not just to identify the most common crystallisation conditions for membrane proteins in general, but also to analyse the differences in growth conditions between functionally-related sub-groups in a statistically robust manner. This has resulted in the development of a new generation of screens from Prof Newstead that target important groups of α-helical membrane proteins.


MemChannel™

The best screen for your ion channel protein:
  • Based on approximately 150 ion channel structures in the database.
  • Contains the most commonly occurring ion channel crystallisation conditions to maximise your chances of success.
  • Specifically targeted at this large group of pharmaceutically important structures.
  • Continually updated database3 ensures most recent hit conditions are present.
  • Hand-curated to remove false positives from unrelated structures – only ion channel conditions contribute to the formulation.
Ion channels represent around 30% of all known membrane protein structures. They are responsible for the action potential in all nerve cells (voltage-gated potassium and sodium channels) and have roles to play in as diverse situations as the Ebola virus (TPC2 channels) and, possibly, the effect of neonicotinoids on bees. They are the target for drug discovery efforts for a diverse range of conditions including chronic pain, epilepsy and cardiac arrythmias. MemChannel gives you the best chance of crystallising the member of this group that you are researching.

MemTrans

The only screen specifically for transporter proteins:

  • The most common crystallisation conditions identified from ~150 transporter protein structures.
  • Contains the most commonly occurring ion channel crystallisation conditions to maximise your chances of success.
  • Specifically targeted at this large group of pharmaceutically important structures.
  • Continually updated database ensures most recent hit conditions are present.
  • Hand-curated database3 to remove false positives from unrelated structures – only ion channel conditions contribute to the formulation.
Approximately 30% of all known membrane protein structures are transporter proteins. They are responsible for moving small molecules across the cell membrane. They are involved in mechanisms of drug uptake and antibiotic resistance and are targets for drug discovery efforst for a diverse range of conditions. MemTrans contains all the most common transporter protein conditions in one place, making crystallising your protein easier.

References



*MemChannel and MemTrans were developed by Prof. Simon Newstead and Dr Joanne Parker of Oxford University and exclusively licensed to Molecular Dimensions Ltd by Oxford University Innovation.

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